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According to the Knight Files, T-Synth is a viral agent developed by rogue Umbrella Corporation scientist Roderick Lazarus. It is one of Lazarus' prize creations, as it is supposedly able to ensure a perfect blending between an organism and the T-Virus. It is unknown whether the T-Synth is able to blend along with any other viral agents, such as the G-Virus or the T-Veronica Virus. Although it is not specifically stated, it is believed that the Fenrir is result of the application of this virus. According to the Knight Files, the only other person who knew of the existance of T-Synth was Christopher McArthur, who was terminated shortly before the virus' production.

Known experiments which use the T-Synth agent include the Mafdet.

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